Clinical Resources
Access our comprehensive collection of evidence-based dose constraints and clinical guidelines.
Dose Constraint Guidelines
The foundational dose/volume tolerance guidelines come from the original QUANTEC reviews, published as a special issue of the International Journal of Radiation Oncology Biology Physics. You can access the full set of organ-specific papers and summary tables on our Publications page.
Organ-Specific Guidelines
Central Nervous System
- Brain stem dose limits
- Optic pathway constraints
- Cochlear dose thresholds
- Cognitive function preservation
Cardiovascular System
- Heart dose constraints
- Pericardial dose limits
- Great vessel guidelines
- Cardiac toxicity models
Respiratory System
- Lung V20/V30 constraints
- Mean lung dose limits
- Pneumonitis risk models
- Trachea/bronchi guidelines
Gastrointestinal System
- Small bowel constraints
- Liver dose limits
- Kidney function preservation
- Gastric dose thresholds
NTCP Models
Normal Tissue Complication Probability (NTCP) models for risk assessment:
Available Models:
- Lyman-Kutcher-Burman Model - Classical NTCP calculation
- Relative Seriality Model - For serial and parallel organs
- Dose-Volume Models - Organ-specific threshold models
- Fractionation Correction Models - BED and EQD2 calculations
Questions or Corrections?
For the underlying clinical evidence, the original QUANTEC papers on our Publications page are the best reference. If you spot an error on this site or have a suggestion, we'd love to hear from you.