QUANTEC Publications

Comprehensive Collection of Quantitative Analysis of Normal Tissue Effects in the Clinic

QUANTEC Special Issue

QUANTEC (Quantitative Analysis of Normal Tissue Effects in the Clinic) reports were published as a special issue of the International Journal of Radiation Oncology Biology Physics (Red Journal), 2010, Vol. 76, No. 3, Supplement.

This issue included 3 introductory, 16 organ-specific and 5 vision papers.

QUANTEC Objective

As described in the introductory QUANTEC paper, "Use of normal tissue probability models in the clinic" by Lawrence B. Marks, Ellen D. Yorke, Andrew Jackson, Randall K. Ten Haken, Louis S. Constine, Avraham Eisbruch, Søren M. Bentzen, Jiho Nam, and Joseph O. Deasy, IJROBP, 2010, Vol. 76, No. 3, Supplement, pp. S10-S19:

"The Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) review summarizes the currently available three-dimensional dose/volume/outcome data to update and refine the normal tissue dose/volume tolerance guidelines provided by the classic Emami et al. paper published in 1991. A 'clinician's view' on using the QUANTEC information in a responsible manner is presented along with a description of the most commonly used normal tissue complication probability (NTCP) models. A summary of organ-specific dose/volume/outcome data, based on the QUANTEC reviews, is included."

Introductory QUANTEC Papers

Guest Editor's Introduction to QUANTEC: A User Guide

Lawrence B. Marks, Randall K. Ten Haken and May K. Martel

Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC): An Introduction to the Scientific Issue

Søren M. Bentzen, Louis S. Constine, Joseph O. Deasy, Avi Eisbruch, Andrew Jackson, Lawrence B. Marks, Randall K. Ten Haken, and Ellen D. Yorke

Use of Normal Tissue Probability Models in the Clinic

Lawrence B. Marks, Ellen D. Yorke, Andrew Jackson, Randall K. Ten Haken, Louis S. Constine, Avraham Eisbruch, Søren M. Bentzen, Jiho Nam, and Joseph O. Deasy

Organ-Specific QUANTEC Papers

Central Nervous System

Head and Neck

Larynx/Pharynx

Abdomen

Pelvis

QUANTEC Summary Tables

Quick reference tables summarizing dose/volume constraints for all organs: