Welcome to QUANTEC Radiation
Our mission is to provide comprehensive, evidence-based radiation dose constraints and guidelines for radiation oncology professionals worldwide.
Our Mission
Building upon the foundation laid by the original QUANTEC (Quantitative Analyses of Normal Tissue Effects in the Clinic) initiative, our goal is to provide introductory, methodology, and vision papers regarding the many issues relating to the quantification of radiation dose effects.
The heart and soul of our work is the analysis of organs and tissues that are at risk for radiation injury, providing clinicians with the tools they need to optimize treatment plans while minimizing complications.
Key Resources & Areas of Focus
CNS Tolerance
Central nervous system dose thresholds and cognitive function preservation strategies.
Head and Neck
Dose-volume-response for xerostomia, hearing loss, edema/fibrosis and dysphagia.
Cardiac Toxicity
Heart dose constraints and radiation-induced cardiac complications.
Pulmonary Effects
Lung dose-volume effects and the reviews behind them.
GI Toxicity
- Esophageal dose-volume correlates
- Liver, stomach and small bowel
- Kidney dose-volume effects
- Rectal toxicity
Genitourinary and Pelvis
- Bladder dose-volume effects
- Rectal toxicity
- Penile bulb
Optic Structures
Optic nerve and chiasm dose-volume-response, grouped with the CNS reviews.
Pediatric Guidelines
PENTEC publications and the PENTEC project website.
NTCP Modeling
Where normal tissue complication probability models are described.
For Healthcare Professionals
Our resources are designed for:
- Radiation Oncologists - The review behind each organ's dose/volume guidance
- Medical Physicists - Primary sources for plan evaluation and safety review
- Dosimetrists - A quick route from an organ at risk to its constraint paper
- Researchers - The QUANTEC literature in one place, plus the QUANTEC 2 scope
- Residents & Trainees - An orientation to where the evidence comes from
Access the Guidelines
Every constraint on this site routes to the peer-reviewed review it comes from. Start with the organ system, or browse the full set of papers.