AllTEC Publications
Normal tissue dose/volume effects across the QUANTEC, HyTEC and PENTEC efforts.
QUANTEC Special Issue
QUANTEC (Quantitative Analysis of Normal Tissue Effects in the Clinic) reports were published as a special issue of the International Journal of Radiation Oncology Biology Physics (Red Journal), 2010, Vol. 76, No. 3, Supplement.
This issue included 3 introductory, 16 organ-specific and 5 vision papers.
QUANTEC Objective
As described in the introductory QUANTEC paper, "Use of Normal Tissue Complication Probability Models in the Clinic" by Lawrence B. Marks, Ellen D. Yorke, Andrew Jackson, Randall K. Ten Haken, Louis S. Constine, Avraham Eisbruch, Søren M. Bentzen, Jiho Nam, and Joseph O. Deasy, IJROBP, 2010, Vol. 76, No. 3, Supplement, pp. S10-S19:
"The Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) review summarizes the currently available three-dimensional dose/volume/outcome data to update and refine the normal tissue dose/volume tolerance guidelines provided by the classic Emami et al. paper published in 1991. A 'clinician's view' on using the QUANTEC information in a responsible manner is presented along with a description of the most commonly used normal tissue complication probability (NTCP) models. A summary of organ-specific dose/volume/outcome data, based on the QUANTEC reviews, is included."
Introductory QUANTEC Papers
Guest Editor's Introduction to QUANTEC: A Users Guide
Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC): An Introduction to the Scientific Issues
Use of Normal Tissue Complication Probability Models in the Clinic
Organ-Specific QUANTEC Papers
Central Nervous System
Brain
Optic Nerve/Chiasm
Brainstem
Spinal Cord
Head and Neck
Thorax
Abdomen
Pelvis
QUANTEC Vision Papers
The third section of the special issue, S135–S160. These are forward-looking papers on future research directions — they carry no dose constraints, so they are not a source for a clinical value.
Accurate Accumulation of Dose for Improved Understanding of Radiation Effects in Normal Tissue
Imaging for Assessment of Radiation-Induced Normal Tissue Effects
Biomarkers and Surrogate Endpoints for Normal-Tissue Effects of Radiation Therapy: The Importance of Dose–Volume Effects
Improving Normal Tissue Complication Probability Models: The Need to Adopt a “Data-Pooling” Culture
The Lessons of QUANTEC: Recommendations for Reporting and Gathering Data on Dose–Volume Dependencies of Treatment Outcome
QUANTEC Summary Tables
Quick reference tables summarizing dose/volume constraints for all organs:
HyTEC
Published as a special issue of the International Journal of Radiation Oncology Biology Physics, Vol. 110, Issue 1. Also available from the AAPM website.
PENTEC
Published as a special issue of the International Journal of Radiation Oncology Biology Physics, Vol. 119, Issue 2. PENTEC also maintains its own website.